Search results for "unilateral nigral lesion"

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The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry

2009

6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to …

Malemedicine.medical_specialtyParkinson's diseaseChromatography High pressure liquidRats as laboratory animalsHippocampusStriatumGeneral Biochemistry Genetics and Molecular BiologyBrain stemLesionRats Sprague-Dawleychemistry.chemical_compoundbrain monoamineHistory and Philosophy of ScienceDopamineInternal medicineCerebellummedicineunilateral nigral lesionAnimalsNeurochemistryratBiogenic MonoaminesOxidopamineChromatography High Pressure Liquidbusiness.industryGeneral NeuroscienceBrainCerebral cortexRatsSubstantia NigraMonoamine neurotransmitterEndocrinologychemistrynervous systemSerotoninmedicine.symptombusinessHippocampus (Brain)NeuroscienceOxidopaminemedicine.drug

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